Pregabalin, a structural derivative of gamma-aminobutyric acid (GABA), does not directly interact with GABA receptors or benzodiazepine receptors. Instead, it binds with high affinity to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. Although its precise mechanism of action is not fully understood, studies suggest that this binding contributes to Pregabalin's anti-seizure and anti-nociceptive effects.
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Safety and efficacy for managing DPN, PHN, spinal cord injury pain, and fibromyalgia in children and adolescents have not been established.
Safety in infants below 1 month of age is not established.
Common side effects in adults include dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and cognitive difficulties (e.g., trouble concentrating). In pediatric patients treated for partial-onset seizures, increased appetite, and weight gain are common.
When discontinuing Pregabalin, taper the dose gradually over at least 1 week to avoid withdrawal symptoms.
Pregabalin is contraindicated in individuals with known hypersensitivity to the drug or its components.
Patients should be cautious when driving or operating machinery due to potential dizziness and drowsiness. Discontinuation of Pregabalin should be gradual to prevent withdrawal or adverse effects.
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of the reach of children.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.